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KMID : 0861020120270030007
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Korea Journal of Herbology
2012 Volume.27 No. 3 p.7 ~ p.13
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Effects of Pear Extracts Containing Herbal Medicine (Lycii Fructus, Coicis Semen, Alimatis Rhizoma, and Astragali Radix) on Body Weight, Lipid Metabolism, and Immune Responses of Rats Fed with High Fat Diets (I)
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Kim Wang-In
Youn Dae-Hwan
Kim Hwang-Gon
Na Chang-Su
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Abstract
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Objective: This study was conducted to observe the anti-hyperlipidemic and anti-inflammatory effects, as well
as the metabolic benefits, of pear extract and herbal drug mixture (Lycii Fructus, Coicis Semen, Alimatis
Rhizoma, and Astragali Radix) on rats fed with a high fat diet.
Methods: The animals used were male rats and the control group was fed a high fat diet only. The
experimental groups were divided into four. ExpⅠ group was fed a high fat diet with a mixture of pear extract
and 3% Lycii Fructus; Exp Ⅱ group was fed a high fat diet with a mixture of pear extract and 3% Coicis
Semen; Exp Ⅲ group was fed a high fat diet with a mixture of pear extract and 3% Alimatis Rhizoma; and
Exp Ⅳ group was fed a high fat diet with a mixture of pear extract and 3% Astragali Radix for 4 weeks.
Results: The body weight gain increased in all groups, but attenuated gradually in the experimental groups
compared to the control group. The food intakes were significantly lower in ExpⅠ and Exp Ⅲ groups than the
control group. The concentrations of serum total cholesterol (TC), HDL-cholesterol, LDL-cholesterol, and
triglyceride (TG) were significantly higher in Exp Ⅱ than in the control group, and lower in Exp Ⅲ group than in
the control group. Also the concentration of serum free fatty acid was significantly lower in the Exp Ⅲ group than
in the control group. In inflammatory activities, the Exp Ⅱ group was significantly lower than the control group.
Conclusion: The results indicated that Exp Ⅲ group (administered a mixture of pear extract and Alimatis
Rhizoma) most efficiently reduced fat accumulation and body weight, while the Exp Ⅱ group (administered the
mixture of pear extract and Coicis Semen) had the highest elevated lipid metabolism and immune activity.
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KEYWORD
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Pear extract, herbal medicine, Lycii Fructus, Coicis Semen, Alimatis Rhizoma, and Astragali Radix, high fat diet, lipid metabolism
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